Large bowel obstruction from advanced prostate cancer in a 41-year-old: the role of genetic testing

Keywords: large bowel obstruction, advanced prostate cancer, genetic testing

Abstract

We report a rare presentation of an advanced prostate cancer (Gleason 10) in a 41-year-old man with complete large bowel obstruction relieved by loop colostomy. His young age prompted a search for a cause and genetic testing confirmed chromosome 10 PTEN deletion. His immediate family members were screened and counselled appropriately. This case outlines the role of genetic testing in young males with prostate cancer.

Author Biographies

J B Jonosky, University of the Witwatersrand

Department of Urology, Helen Joseph Hospital, Department of Paediatric Urology, Rahima Moosa Mother & Child (Coronation) Hospital and Division of Urology, Department of Surgery, Faculty of Health Sciences, University of the Witwatersrand, South Africa

N De Villiers, AMPATH Genetics

AMPATH Genetics, South Africa

R Wadee, University of the Witwatersrand

Division of Anatomical Pathology, University of the Witwatersrand and National Health Laboratory Services (NHLS), South Africa

F Chinegwundoh, Barts Health NHS Trust

Department of Urology, Barts Health NHS Trust, United Kingdom

A Adam, University of the Witwatersrand

Department of Urology, Helen Joseph Hospital, Department of Paediatric Urology, Rahima Moosa Mother & Child (Coronation) Hospital and Division of Urology, Department of Surgery, Faculty of Health Sciences, University of the Witwatersrand, South Africa

Published
2020-10-19
How to Cite
Jonosky, J., De Villiers, N., Wadee, R., Chinegwundoh, F., & Adam, A. (2020). Large bowel obstruction from advanced prostate cancer in a 41-year-old: the role of genetic testing. South African Journal of Surgery, 58(3), 163. Retrieved from http://sajs.redbricklibrary.com/index.php/sajs/article/view/3181
Section
Case Reports