Oesophageal cancer in Area 2 of KwaZulu-Natal: predictors of late presentation

  • Lucien Ferndale University of KwaZulu-Natal
  • Benn Sartorius University of KwaZulu-Natal
  • Colleen Aldous University of KwaZulu-Natal
  • Sandie Thomson University of Cape Town
Keywords: Oesophageal cancer, KwaZulu-Natal, predictors, late presentation

Abstract

Background: There are limited prospective data sets on clinical characteristics, stage of presentation and treatment of patients with Oesophageal Squamous Cell Carcinoma (OSCC) in South Africa. This study aimed to  assess the frequency and severity of clinical characteristics associated with late presentation of patients with OSCC presenting to a cancer referral centre in KwaZulu-Natal, South Africa.

Methods: A prospective consecutive series of patients presenting with confirmed OSCC treated at Greys Hospital in 2016/2017 were enrolled. Data collected included: age, gender, home language, referral centre, clinical and laboratory characteristics: dysphagia score, Eastern Cooperative Oncology Group (ECOG) performance status, body mass index (BMI), serum albumin, tumour pathology and treatment administered.

Results: One hundred patients were analysed. Ninety four percent spoke isiZulu. The mean age was 61 with a male to female ratio of 1.5:1 Ninety percent had palliative treatment as their overall assessment precluded curative treatment. Five patients underwent curative treatment. The age standardised incidence (ASR) was 25.2 per 100 000. The factors associated with late presentation and their frequency were: advanced dysphagia grade ( >/=2 in 68%), malnutrition (BMI <18.5kg/m2 in 49%), hypoalbuminaemia (serum albumin < 35 g/l in 70%), poor performance status (ECOG>/=2 in 50% ) and moderate to poor tumour differentiation in 95% of patients.

Conclusions: OSCC in KwaZulu-Natal has double the ASR of South Africa and places a significant burden on the region’s health care system. Factors associated with late presentation occur in the majority and alone or in combination preclude curative therapies. The frequency of these factors serve as a benchmark for comparison, and reduction in their frequency may indicate effectiveness of interventions designed to improve awareness and access to proper care.

Author Biographies

Lucien Ferndale, University of KwaZulu-Natal

Department of Surgery, Greys Hospital and School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa

Benn Sartorius, University of KwaZulu-Natal

Discipline of Public Health Medicine, School of Nursing and Public Health, University of KwaZulu-Natal, Durban,
South Africa

Colleen Aldous, University of KwaZulu-Natal

School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa

Sandie Thomson, University of Cape Town

Division of Gastroenterology, Department of Medicine, University of Cape Town, South Africa

Published
2019-04-24
How to Cite
Ferndale, L., Sartorius, B., Aldous, C., & Thomson, S. (2019). Oesophageal cancer in Area 2 of KwaZulu-Natal: predictors of late presentation. South African Journal of Surgery, 57(2), 4-9. Retrieved from http://sajs.redbricklibrary.com/index.php/sajs/article/view/2948
Section
General Surgery