Time since injury is the major factor in preventing tranexamic acid use in the trauma setting: An observational cohort study from a major trauma centre in a middle-income country

  • Ben Thurston Trinity College, Oxford University, UK
  • Sharfuddin Chowdhury Trauma Center, Groote Schuur Hospital and University of Cape Town, Health Sciences Faculty
  • Sorin Edu Trauma Center, Groote Schuur Hospital and University of Cape Town, Health Sciences Faculty
  • Andrew J Nicol Trauma Center, Groote Schuur Hospital and University of Cape Town, Health Sciences Faculty
  • Pradeep Harkison Navsaria Trauma Center, Groote Schuur Hospital and University of Cape Town, Health Sciences Faculty
Keywords: tranexamic acid, trauma, coagulopathy

Abstract

Background. Haemorrhage is responsible for about a third of in-hospital trauma deaths. The CRASH-2 trial demonstrated that early administration of tranexamic acid, ideally within 3 hours, can reduce mortality from trauma-associated bleeding by up to 32%.

Objective. To explore whether, in our trauma network in a middle-income country, patients arrived at hospital soon enough after injury for tranexamic acid administration to be effective and safe.

Methods. A prospective cohort study of 50 consecutive patients admitted to our trauma unit was undertaken. Inclusion criteria were as for the CRASH-2 study: systolic blood pressure <90 mmHg and/or heart rate >110 beats per minute, with injuries suggestive of a risk of haemorrhage. Patients with isolated head injuries were excluded. The mechanisms of injury, time since injury and any reasons for delay were recorded.

Results. Thirteen (26%) patients presented early enough for tranexamic acid administration. Of these, only three patients presented within the 1st hour. Eleven patients had a documented time of injury >3 hours prior to presentation. We were unsure of the time of injury for 26 patients, although for most of these it was likely to be >3 hours before presentation.

Conclusions. The majority (74%) of bleeding trauma patients did not present within the timeframe allowed for safe administration of tranexamic therapy. Of those who did, most would have benefited from even earlier commencement of therapy. This raises the possibility that tranexamic acid may be more effective on a population basis if incorporated into prehospital rather than in-hospital protocols; future studies should explore the benefits and risks of this approach

Author Biographies

Ben Thurston, Trinity College, Oxford University, UK
MA, BMBCh
Sharfuddin Chowdhury, Trauma Center, Groote Schuur Hospital and University of Cape Town, Health Sciences Faculty
MBChB, FCS
Sorin Edu, Trauma Center, Groote Schuur Hospital and University of Cape Town, Health Sciences Faculty
MBChB, FCS
Andrew J Nicol, Trauma Center, Groote Schuur Hospital and University of Cape Town, Health Sciences Faculty
MBChB, PhD, FCS
Pradeep Harkison Navsaria, Trauma Center, Groote Schuur Hospital and University of Cape Town, Health Sciences Faculty
MBChB, MMed, FCS, FACS, Trauma Surgery
Published
2015-10-08
How to Cite
Thurston, B., Chowdhury, S., Edu, S., Nicol, A., & Navsaria, P. (2015). Time since injury is the major factor in preventing tranexamic acid use in the trauma setting: An observational cohort study from a major trauma centre in a middle-income country. South African Journal of Surgery, 53(1), 13-18. Retrieved from http://sajs.redbricklibrary.com/index.php/sajs/article/view/1893
Section
Vascular Surgery