Association between low serum free testosterone and adverse prognostic factors in men diagnosed with prostate cancer in KwaZulu-Natal

  • M M Alsharef Department of Urology, Grey’s Hospital, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Pietermaritzburg
  • A Kahie Department of Urology, Grey’s Hospital, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Pietermaritzburg
  • M Conradie Department of Urology, Grey’s Hospital, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Pietermaritzburg
  • E A Goad Department of Urology, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban
  • T Fourie Department of Urology, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban
Keywords: prostate cancer, prostate biopsy, free testosterone (FT), Gleason score

Abstract

Background. The association of serum free testosterone (FT) with prostate cancer is not fully understood. Studies on the results of the relationship between serum testosterone level and prostate cancer are conflicting. However, there is a reported association between lower serum testosterone levels and high-grade prostate cancer. Objective. To investigate the relationship between serum FT and the clinico-pathological characteristics of prostate cancer in South African patients. Materials and methods. The clinical data of 109 consecutive patients diagnosed with prostate cancer on biopsy were evaluated prospectively. The variables were age, ethnic group, prostate specific antigen (PSA), digital rectal examination (DRE) findings, clinical tumour, nodes and metastases (TNM) stage, and Gleason score. Low serum FT was defined as <250ng/dl. Statistical analysis was performed using Stata V10 software (p<0.05 considered significant). Results. There was a statistically significant association between low serum FT and high serum PSA, high Gleason score and clinically advanced stage prostate cancer. Conclusions. In this cohort of men with histologically diagnosed prostate cancer, low serum FT was associated with higher PSA, higher grade, and locally advanced or metastatic prostate cancer.

Author Biographies

M M Alsharef, Department of Urology, Grey’s Hospital, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Pietermaritzburg
Department of Urology Grey’s Hospital, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Pietermaritzburg
A Kahie, Department of Urology, Grey’s Hospital, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Pietermaritzburg
Department of Urology Grey’s Hospital, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Pietermaritzburg
M Conradie, Department of Urology, Grey’s Hospital, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Pietermaritzburg
Department of Urology Grey’s Hospital, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Pietermaritzburg
E A Goad, Department of Urology, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban
Department of Urology, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal
T Fourie, Department of Urology, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban
Department of Urology, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal
Published
2012-03-29
How to Cite
Alsharef, M., Kahie, A., Conradie, M., Goad, E., & Fourie, T. (2012). Association between low serum free testosterone and adverse prognostic factors in men diagnosed with prostate cancer in KwaZulu-Natal. South African Journal of Surgery, 50(2), 40-42. https://doi.org/10.7196/sajs.968
Section
Urology